Nano Fat Grafting and Its Benefits to Facial Rejuvenation

What is Nano Fat Grafting?

Nanofat grafting refers to a minimally invasive procedure to restore volume to the face or body, counteracting the signs of aging. It involves harvesting fat from one part of the body and injecting it into another.
The fat is carefully processed to ensure it’s rich in stem cells. These specialist cells have the ability to become several different kinds of cells, filling in the roles needed by the skin. The result? Fewer lines and wrinkles, reduced dark circles, and a more elastic, youthful neck and neckline.

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    How Nano Fat Grafting Works

    Nano fat grafting involves three steps:

    Fat Harvesting – Fat is collected from the abdomen, thighs, or flanks via liposuction. High-fat areas are chosen to optimize collection.
    Processing – Next, the harvested fat is taken from the body for purification. The fat undergoes filtration and centrifugation to remove any impurities, excess oil, and other unwanted components. The end result is liquid rich in fat cells, stem cells, and other life-giving chemical compounds. It’s then emulsified to create a very fine, smooth solution.
    Injection – Finally, the processed fat (now in nano form) is injected into the target areas to bolster skin quality and rejuvenate the person’s appearance. Common locations to inject the fat cells are the face, hands, neck, and any other regions. Usually, the fat is injected where the signs of ageing are greatest.

    The most important step – which differentiates the procedure from others – is the processing. The purification and emulsification not only remove potentially toxic impurities but also create nanofat.

    Growth Factors in Skin Rejuvenation

    What makes nanofat so special? The answer is the rich cocktail of adipose-derived stem cells (ADSCs) and growth factors found in the fraction. Together, these cells and life-giving compounds help restore the skin.

    Two main growth factors influence the skin’s rejuvenation: vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF).

    VEGF stimulates the growth of new blood vessels, improving the blood supply and nutrient delivery to the skin. This is crucial for removing toxins and providing the right environment for a more youthful appearance. On the other hand, PDGF activates fibroblasts and boosts collagen production. Collagen is the protein that provides the skin with structure, reducing the appearance of fine lines and wrinkles.

    Other helpful growth factors include epidermal growth factor (stimulates cell growth and skin renewal), fibroblast growth factor (promotes collagen and elastin production) and transforming growth factor beta (involved in collagen production and skin repair).

    Benefits of Facial Rejuvenation With Nano Fat

    Why choose nano fat grafting? The results speak for themselves when you look in the mirror. This minimally invasive procedure avoids the risks of more invasive surgeries, providing a simple and effective way to rejuvenate your skin.

    Let’s take a closer look at the benefits:

    • Nano-fat grafting guarantees natural results, using the patient’s own fat in the process. Unlike fillers or face lifts, the results don’t give a plastic-looking end result. Just a more youthful complexion.
    • Using autologous fat (from the patient’s body) reduces the risk of allergic reactions or rejections. There are no additional chemicals involved – only nutrient- and growth-factor-rich nanofat.
    • The fine fat particles contain stem cells and growth factors known to boost skin texture, tone, and overall appearance. These same growth factors and stem cells already work inside your body, repairing and rejuvenating other areas.
    • Compared to other surgeries and procedures, the results of nano fat grafting are relatively long-lasting. Synthetic fillers are usually processed and removed from the body much faster.

    As a general rule, the procedure is effective in targeting wrinkles areas with visible signs of aging. Usually, patients prefer to inject the fat into the face or hands. In the face, the procedure smooths out wrinkles, enhances skin texture, and even adds volume to areas like the cheeks, under the eyes, and around the mouth. Similar results are seen in the hands.
    You may also consider nano fat grafting to reduce the appearance of significant scars. It encourages the breakdown of scar tissue, minimizing its appearance.

    Pros and Cons Compared to Other Facial Rejuvenation Techniques

    Technique Pros Cons
    Nano Fat Grafting Natural results, low allergy risk, skin quality improvement, long-lasting Requires fat harvesting, longer procedure time, potential for uneven results
    Synthetic Fillers Immediate results, no harvesting needed, less invasive Temporary results, potential allergic reactions, may require frequent touch-ups
    Laser Resurfacing Improves skin texture and tone, stimulates collagen Risk of burns/scarring, downtime for healing, not suitable for all skin types
    BTA Effective for dynamic wrinkles, quick procedure, minimal downtime Temporary results, requires regular maintenance, only addresses wrinkles caused by muscle movement

    Good Candidates for Nano Fat Grafting

    The prime candidate for nano fat grafting is someone with mild to moderate signs of aging. While nano-fat grafting can reduce facial wrinkles and fine lines, it struggles to tackle more advanced signs of aging. However, for individuals seeking a natural treatment with minimal side effects to their overall health the procedure is perfect. People should also have realistic expectations, be non-smokers, and have good skin elasticity. You’ll have to follow the post-procedure care to the letter to get the best results.

    The Procedure and Aftercare

    Every procedure begins with an initial consultation and evaluation. Your cosmetician will inspect your skin, advising on the suitability of the procedure. They’ll identify areas to harvest the fat and a plan for injections.

    The procedure is performed under local anesthesia. Usually, it takes around 30 minutes to 1 hour to complete. It should not leave any lasting damage.

    Once complete, you should notice immediate effects in terms of swelling and bruising. However, this should settle after a few days to a week. Recovery involves resting the face, avoiding excess sun exposure, and eating a healthy diet.

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    Nano Fat Grafting At Interplast Clinic

    Discover the transformative potential of nano fat grafting at Interplast Clinic in Bangkok. If you’re looking to enhance your facial contours, reduce the appearance of fine lines, or achieve a more youthful, natural look, our expert plastic surgeons are here to help. Book a consultation today to learn how nano fat grafting can rejuvenate your appearance with minimal downtime and lasting results.

    Contact our expert team today for more information.

    References: 

    Jeyaraman M, Muthu S, Sharma S, Ganta C, Ranjan R, Jha SK. Nanofat: A therapeutic paradigm in regenerative medicine. World Journal of Stem Cells. 2021 Nov 26;13(11):1733-1746. https://www.wjgnet.com/1948-0210/full/v13/i11/1733.htm

    Republished in:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641019/

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